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Literature summary extracted from

  • Zhang, X.; Zhang, K.; Zhang, Y.
    Pigment epithelium-derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2 A potential treatment strategy for missed abortion (2020), Int. J. Mol. Med., 45, 1436-1446 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.4.14 medicine lipopolysaccharide-induced human chorionic trophoblast HTR8/SVneo cell model to mimic missed abortion in vitro. CMPK2 expression and NLRP3 inflammasome activation, downstream pro-IL-18 and pro-IL-1beta expression, and IL-18 and IL-1beta release, are all significantly increased in missed abortion tissues or LPS-induced HTR8/SVneo cells. Pigment epithelium-derived factor reverses the increase in CMPK2 expression and activation of the NLRP3 inflammasome axis and downregulates the production of mitochondrial reactive oxygen species and mitochondrial DNA release Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.4.14 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.14 Homo sapiens Q5EBM0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.14 chorion
-
 Homo sapiens
-
2.7.4.14 decidua
-
 Homo sapiens
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Expression

EC Number Organism Comment Expression
2.7.4.14 Homo sapiens CMPK2 expression and NLRP3 inflammasome activation, downstream pro-IL-18 and pro-IL-1beta expression, and IL-18 and IL-1beta release, are all significantly increased in missed abortion tissues or LPS-induced HTR8/SVneo cells. Pigment epithelium-derived factor reverses the increase in CMPK2 expression up